Thompson G, Mohammed H, Bauman B, Naqi S
Department of Avian and Aquatic Animal Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Avian Dis. 1997 Jul-Sep;41(3):519-27.
Serum and local (respiratory) antibody responses to infectious bronchitis virus (IBV) were studied in 5-wk-old white leghorn-type control chickens and chickens inoculated with infectious bursal disease virus (IBDV) at 1 day of age. Of the chickens inoculated with IBV alone, 93% had detectable levels of IBV antibodies in the sera and 87% had detectable antibodies in the respiratory lavage fluids. Compared to this group, only 73% and 65% of IBDV-IBV inoculated chickens had serum and respiratory antibodies, respectively. In chickens inoculated with IBV alone, the IBV antibodies were evenly associated with immunoglobulin classes IgM, IgG, and IgA, whereas the IBDV-IBV inoculated chickens mainly produced IgM-associated antibodies with low to negligible levels of IgA- and IgG-associated antibodies. These results suggest that the lack of adequate IgA- and IgG-associated antibody production in IBDV-infected chickens may account for their increased susceptibility to IBV infection.
在5周龄的白来航型对照鸡和1日龄接种传染性法氏囊病病毒（IBDV）的鸡中，研究了对传染性支气管炎病毒（IBV）的血清和局部（呼吸道）抗体反应。仅接种IBV的鸡中，93%的血清中可检测到IBV抗体水平，87%的呼吸道灌洗液中可检测到抗体。与该组相比，接种IBDV - IBV的鸡分别只有73%和65%有血清和呼吸道抗体。在仅接种IBV的鸡中，IBV抗体与免疫球蛋白类别IgM、IgG和IgA均匀相关，而接种IBDV - IBV的鸡主要产生与IgM相关的抗体，与IgA和IgG相关的抗体水平低至可忽略不计。这些结果表明，IBDV感染鸡中缺乏足够的与IgA和IgG相关的抗体产生可能是它们对IBV感染易感性增加的原因。
