Graves M, Robin T, Chipman A M, Wong J, Khashe S, Janda J M
Microbial Diseases Laboratory, California Department of Health Services, Berkeley 94704-1011, USA.
Clin Infect Dis. 1997 Oct;25(4):838-42. doi: 10.1086/515551.
Burkholderia gladioli has only recently been reported to be a human pathogen. Four cases of B. gladioli infection (including bacteremia, pneumonia, and cervical adenitis) in two adults and two young children are reported. Three of these four patients were severely immunocompromised. Commercial systems were frequently unable to identify this bacterium correctly. Antimicrobial susceptibility patterns indicated that B. gladioli strains were susceptible to the quinolones, aminoglycosides, and imipenem. In vitro laboratory investigations demonstrated that B. gladioli strains were susceptible to complement-mediated lysis of pooled human serum, thus implying that healthy individuals should be immune to infection. These four cases together with three previously reported cases suggest that B. gladioli primarily causes disease in severely immunocompromised individuals. The lack of mortality associated with infection, coupled with susceptibility to serum and lack of recognizable virulence-associated factors, suggests that this species has a low pathogenic potential.
唐菖蒲伯克霍尔德菌直到最近才被报道为一种人类病原体。本文报告了两例成人和两名幼儿感染唐菖蒲伯克霍尔德菌的病例（包括菌血症、肺炎和颈部腺炎）。这四名患者中有三名存在严重免疫功能低下的情况。商业系统常常无法正确识别这种细菌。抗菌药敏模式表明，唐菖蒲伯克霍尔德菌菌株对喹诺酮类、氨基糖苷类和亚胺培南敏感。体外实验室研究表明，唐菖蒲伯克霍尔德菌菌株对人混合血清的补体介导裂解敏感，因此意味着健康个体应能抵抗感染。这四例病例以及之前报道的三例病例表明，唐菖蒲伯克霍尔德菌主要在严重免疫功能低下的个体中引起疾病。感染相关的死亡率较低，加上对血清敏感且缺乏可识别的毒力相关因子，表明该菌种的致病潜力较低。
