Main M L, Escobar J F, Hall S A, Grayburn P A
Department of Medicine, UT Southwestern Medical Center, Dallas 75235-9047, USA.
J Am Soc Echocardiogr. 1997 Oct;10(8):798-804. doi: 10.1016/s0894-7317(97)70038-5.
The aim of this study was to evaluate the safety and efficacy of QW7437, a new fluorocarbon-based transpulmonary myocardial echocardiographic contrast agent. QW7437 is an anionically charged 2% dodecafluoropentane emulsion molecule, similar to EchoGen, a contrast agent previously shown to be efficacious in providing myocardial opacification by means of venous injection. This new agent has theoretical potential to provide greater safety and efficacy as a result of (1) reduced adherence to the negatively charged vascular endothelium and (2) reduced microbubble coalescence. Myocardial contrast echocardiography was performed in 10 dogs to evaluate the safety and efficacy of this agent. QW7437 (0.05 ml/kg) was injected as an intravenous bolus during intermittent harmonic epicardial imaging. Hemodynamic variables including heart rate, blood pressure, pulmonary artery pressure, pulmonary capillary wedge pressure, cardiac output, and arterial blood gases were determined at baseline and serially after contrast administration. Left ventricular fractional area shortening the regional myocardial blood flow at rest and during hyperemia (adenosine 140 micrograms/kg/min) were measured before and after contrast echocardiography. QW7437 provided dense myocardial opacification which persisted for more than 2 minutes in all subjects. This prolonged contrast effect did not result in significant changes in any hemodynamic variables, left ventricular function, or myocardial blood flow. Future studies should address the potential of this agent for human use.
本研究的目的是评估QW7437的安全性和有效性。QW7437是一种新型的基于氟碳的经肺心肌超声心动图造影剂。QW7437是一种带阴离子电荷的2%十二氟戊烷乳剂分子，类似于EchoGen，一种先前已证明通过静脉注射可有效实现心肌显影的造影剂。由于（1）减少了与带负电荷的血管内皮的粘附以及（2）减少了微泡聚并，这种新型造影剂具有提供更高安全性和有效性的理论潜力。对10只犬进行了心肌对比超声心动图检查以评估该造影剂的安全性和有效性。在间歇性谐波心外膜成像期间，将QW7437（0.05 ml/kg）作为静脉推注给药。在基线时以及造影剂给药后连续测定血流动力学变量，包括心率、血压、肺动脉压、肺毛细血管楔压、心输出量和动脉血气。在对比超声心动图检查前后测量左心室缩短分数、静息和充血（腺苷140微克/千克/分钟）时的局部心肌血流量。QW7437在所有受试者中均提供了致密的心肌显影，且持续超过2分钟。这种延长的对比效果并未导致任何血流动力学变量、左心室功能或心肌血流量发生显著变化。未来的研究应探讨该造影剂用于人体的潜力。
