Varshavsky A
Division of Biology, California Institute of Technology, Pasadena 91125, USA.
Trends Biochem Sci. 1997 Oct;22(10):383-7. doi: 10.1016/s0968-0004(97)01122-5.
Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.
真核生物含有一个高度保守的多酶系统，该系统将泛素共价连接到多种带有被此系统识别的降解信号的细胞内蛋白质上。由此产生的泛素 - 蛋白质缀合物被26S蛋白酶体降解，26S蛋白酶体是一种大型的依赖ATP的蛋白酶。涉及泛素的通路是众多过程的基础，包括细胞分化、细胞周期和应激反应。
