Villa P, Kaufmann S H, Earnshaw W C
Institute of Cell and Molecular Biology, University of Edinburgh, UK.
Trends Biochem Sci. 1997 Oct;22(10):388-93. doi: 10.1016/s0968-0004(97)01107-9.
Five years ago, little was known about mechanisms of apoptotic execution. Now, one class of cell-death gene, the cysteine and aspartases (caspases) has come under intensive study. This review discusses the two classes of caspases, the reasons why humans may have so many caspase genes, the growing list of caspase substrates, and viral and pharmacological caspase inhibitors.
五年前，人们对凋亡执行机制知之甚少。如今，一类细胞死亡基因——半胱天冬酶（caspases）已成为深入研究的对象。本文综述了两类半胱天冬酶、人类可能拥有众多半胱天冬酶基因的原因、不断增加的半胱天冬酶底物清单，以及病毒和药理学半胱天冬酶抑制剂。
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