Pan Jing-Yu, Sun Cheng-Cao, Bi Zhuo-Yue, Chen Zhen-Long, Li Shu-Jun, Li Qing-Qun, Wang Yu-Xuan, Bi Yong-Yi, Li De-Jia
Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan 430071 Hubei, P.R. China.
Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan 430071 Hubei, P.R. China.
Mol Ther Nucleic Acids. 2017 Sep 15;8:442-449. doi: 10.1016/j.omtn.2017.06.002. Epub 2017 Jun 7.
Lung cancer is a deadly disease that ends numerous lives around the world. MicroRNAs (miRNAs) are a group of non-coding RNAs involved in a variety of biological processes, such as cell growth, organ development, and tumorigenesis. The miR-206/133b cluster is located on the human chromosome 6p12.2, which is essential for growth and rebuilding of skeletal muscle. The miR-206/133b cluster has been verified to be dysregulated and plays a crucial role in lung cancer. miR-206 and miR-133b participate in lung tumor cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. The mechanisms are sophisticated, involving various target genes and molecular pathways, such as MET, EGFR, and the STAT3/HIF-1α/VEGF signal pathway. Hence, in this review, we summarize the role and potential mechanisms of the miR-206/133b cluster in lung cancer.
肺癌是一种致命疾病，在全球夺走了无数人的生命。微小RNA（miRNA）是一类参与多种生物学过程的非编码RNA，如细胞生长、器官发育和肿瘤发生。miR-206/133b簇位于人类染色体6p12.2上，对骨骼肌的生长和重建至关重要。miR-206/133b簇已被证实存在失调，并在肺癌中起关键作用。miR-206和miR-133b参与肺肿瘤细胞的凋亡、增殖、迁移、侵袭、血管生成、耐药性及癌症治疗。其机制复杂，涉及多种靶基因和分子途径，如MET、EGFR以及STAT3/HIF-1α/VEGF信号通路。因此，在本综述中，我们总结了miR-206/133b簇在肺癌中的作用及潜在机制。
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