Lupas A, Flanagan J M, Tamura T, Baumeister W
Smithkline Beecham Pharmaceuticals, Collegeville, PA 19426-0989, USA.
Trends Biochem Sci. 1997 Oct;22(10):399-404. doi: 10.1016/s0968-0004(97)01117-1.
Among the hundreds of proteases characterized so far, most of which are monomeric or dimeric, there is a small group that form compartments through self-association and that segregate their proteolytic active sites to the interior of these compartments. Although few in number, they represent the main agents of intracellular protein breakdown. They belong to different hydrolase families but have converged towards the same barrel-shaped architecture. Frequently, they are coupled to chaperone-like ATPases of similar quaternary structure that regulate the access to the proteolytic compartments and appear to have been recruited from the same branch of P-loop NTPases.
在迄今为止已鉴定的数百种蛋白酶中，大多数是单体或二聚体，有一小类通过自我缔合形成区室，并将其蛋白水解活性位点分隔在这些区室内部。尽管数量不多，但它们是细胞内蛋白质分解的主要介质。它们属于不同的水解酶家族，但已趋同于相同的桶状结构。通常，它们与具有相似四级结构的伴侣样ATP酶偶联，这些ATP酶调节进入蛋白水解区室的通道，并且似乎是从P环NTP酶的同一分支招募而来的。
