Südi J
Institut für Toxikologie, Christian Albrechts Universität, Kiel, Germany.
Biochim Biophys Acta. 1997 Sep 5;1341(2):108-36. doi: 10.1016/s0167-4838(97)00053-8.
The algebraic rate equations of steady-state enzyme kinetics generally allow the derivation of analytical expressions for the distribution of rate control among the elementary reactions defined by the kinetic mechanism. It is shown that these analytical expressions complete the macroscopic (probabilistic) description of enzyme-catalysed chemical reactions without involving any assumption at the microscopic (molecular) level. By also surveying some directly relevant results of the graph theoretical treatment of enzyme mechanisms, it is shown that control analysis is an integral part of steady-state enzyme kinetics.
稳态酶动力学的代数速率方程通常允许推导动力学机制所定义的基本反应之间速率控制分布的解析表达式。结果表明，这些解析表达式完善了酶催化化学反应的宏观（概率性）描述，而无需涉及微观（分子）层面的任何假设。通过考察酶机制的图论处理的一些直接相关结果，表明控制分析是稳态酶动力学的一个组成部分。
