基于伪稳态假设和快速平衡假设对酶反应速率方程进行计算机推导。
The computerized derivation of rate equations for enzyme reactions on the basis of the pseudo-steady-state assumption and the rapid-equilibrium assumption.
作者信息
Ishikawa H, Maeda T, Hikita H, Miyatake K
机构信息
Department of Chemical Engineering, University of Osaka Prefecture, Japan.
出版信息
Biochem J. 1988 Apr 1;251(1):175-81. doi: 10.1042/bj2510175.
Abstract
A computer program is developed for the derivation of the rate equation for enzyme reactions on the basis of the pseudo-steady-state assumption and the combination of the pseudo-steady-state and the rapid-equilibrium assumptions. The program not only has an easy input method, but also can obtain a complete rate equation in itself on only one run. The usefulness of the program is demonstrated by deriving the rate equations for some typical enzyme reactions. Details of the program have been deposited as Supplementary Publication SUP 50141 (42 pages) at the British Library Lending Division, Boston Spa, Wetherby, West Yorkshire LS23 7QB, U.K., from whom copies may be obtained as indicated in Biochem. J. (1988), 249, 5.
摘要
开发了一个计算机程序，用于基于伪稳态假设以及伪稳态和快速平衡假设的组合来推导酶反应的速率方程。该程序不仅具有简便的输入方法，而且只需运行一次就能自行得到完整的速率方程。通过推导一些典型酶反应的速率方程证明了该程序的实用性。该程序的详细内容已作为补充出版物SUP 50141（42页）存放在英国西约克郡韦瑟比波士顿温泉市大英图书馆出借部，邮编LS23 7QB，可按《生物化学杂志》（1988年）第249卷第5期所示方式从该处获取副本。
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本文引用的文献
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The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.具有两种或更多种底物或产物的酶催化反应动力学。I. 命名法和速率方程。
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