Tay A H, Lim L C, Lee W L, Wong K E, Wong L Y, Tsoi W F
Institute of Molecular and Cell Biology, National University of Singapore, Republic of Singapore.
Hum Hered. 1997 Sep-Oct;47(5):298-300. doi: 10.1159/000154428.
The T102C polymorphism at the 5-hydroxytryptamine 2a receptor (5HTR2a) gene was studied in 101 Chinese male schizophrenics and 103 controls. Genotyping revealed a predominance of allele 1 among schizophrenics. This is in contrast to previous reports in Caucasians and Japanese which showed an association of allele 2 of this polymorphism with schizophrenia.
在101名中国男性精神分裂症患者和103名对照者中,对5-羟色胺2a受体(5HTR2a)基因的T102C多态性进行了研究。基因分型显示,精神分裂症患者中1等位基因占优势。这与之前在高加索人和日本人中的报道形成对比,之前的报道显示该多态性的2等位基因与精神分裂症有关。