Red cell organic phosphates during administration of salicylates.

The effect of salicylates on erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP) was studied in vivo in 3 groups of healthy subjects receiving acetylsalicyclic acid (18 persons), sodium salicylate (5 persons) and salicylamide (7 persons) in therapeutic dosage. No effect was found on 2,3-DPG in any of the 3 groups. ATP was significantly decreased (p less than 0.05) when acetylsalicylic acid or sodium salicylate was given.