Schück O, Bohdanecká M, Sedivý J, Krajícková M, Chadimová M, Matousovic K
Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Eur J Drug Metab Pharmacokinet. 1997 Jul-Sep;22(3):207-9. doi: 10.1007/BF03189808.
Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsible for reduced CyA availability under these conditions have not yet been identified.
实验性慢性肾功能不全（由肾实质5/6切除产生）与口服（胃内）环孢素A（CyA）的动力学变化有关。与肾实质完整的动物相比，在这些条件下达到的CyA水平显著更低。在这些条件下导致CyA可利用性降低的因素尚未确定。
