Cohen T J, Goldner B, Merkatz K, Jadonath R, Adler H, Ehrlich J C
Department of Medicine, North Shore University Hospital, Manhasset, New York, USA.
Pacing Clin Electrophysiol. 1997 Oct;20(10 Pt 1):2412-8. doi: 10.1111/j.1540-8159.1997.tb06079.x.
The purpose of this study was to determine whether a simple ECG algorithm could be developed for predicting susceptibility to ventricular tachyarrhythmias (VT) as defined by sustained spontaneous or inducible VT. Two different QT dispersion algorithms were determined by the difference between the longest and shortest QT interval measured in three orthogonal leads (I, aVF, V1; QTD3), and at least 11 of 12 leads (QTD12) from the 12-lead ECG. These QT dispersion algorithms were investigated (with and without the QRS duration from the 12-lead ECG) and compared to the signal-averaged ECG (SAECG) in order to determine their sensitivity and specificity for detecting VT. Only patients who underwent SAECG and were referred for programmed electrical stimulation were included in this study. A positive SAECG was defined by filtered QRS duration > 114 ms, and/or low amplitude signal duration > 38 ms, and/or root mean square voltage in the last 40 ms of < 20 microV. Sixty patients were enrolled in this study with a mean age of 63 +/- 2 years. Fifty-five percent of the patients had coronary artery disease. A simple ECG algorithm consisting of the sum of QTD3 plus the QRS duration had a sensitivity and specificity of 90% and 63%, respectively, wheras the SAECG had a sensitivity and specificity of 60% and 63%, respectively (P = 0.022). We conclude that a simple ECG algorithm is more sensitive than the SAECG for predicting VT. This algorithm combines two easily measured variables obtained from the 12-lead ECG, and can easily be performed without expensive computer equipment.
本研究的目的是确定是否可以开发一种简单的心电图算法,用于预测由持续性自发或诱发性室性心动过速(VT)定义的室性快速心律失常易感性。两种不同的QT离散度算法分别由在三个正交导联(I、aVF、V1;QTD3)以及12导联心电图中至少11个导联(QTD12)测量的最长和最短QT间期之差确定。对这些QT离散度算法(有或无12导联心电图的QRS时限)进行了研究,并与信号平均心电图(SAECG)进行比较,以确定它们检测VT的敏感性和特异性。本研究仅纳入接受了SAECG检查并被转诊进行程序电刺激的患者。SAECG阳性的定义为滤波后的QRS时限>114 ms,和/或低振幅信号时限>38 ms,和/或最后40 ms的均方根电压<20微伏。本研究共纳入60例患者,平均年龄63±2岁。55%的患者患有冠状动脉疾病。一种由QTD3与QRS时限之和组成的简单心电图算法的敏感性和特异性分别为90%和63%,而SAECG的敏感性和特异性分别为60%和63%(P = 0.022)。我们得出结论,在预测VT方面,一种简单的心电图算法比SAECG更敏感。该算法结合了从12导联心电图获得的两个易于测量的变量,并且无需昂贵的计算机设备即可轻松执行。