Hsieh M T, Lu S P, Peng W H, Chang K H, Pan I H
Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan.
Am J Chin Med. 1997;25(3-4):343-50. doi: 10.1142/S0192415X9700038X.
The biphasic effects of Pu-Chung-I-Chi-Tang (PCT) on sedation and excitation in acute treatment or after one-week consecutive treatment were studied. The results indicated that PCT produces sedation in acute treatment and excitation after one-week consecutive treatment. The sedative mechanism of PCT in acute treatment might be due to an increase in serotonergic activity and a decrease in dopaminergic activity. However, the excitatory mechanism of PCT after one-week consecutive treatment might involve the increase in dopaminergic activity and the decrease in serotonergic activity.
研究了朴中益气汤（PCT）在急性治疗或连续治疗一周后对镇静和兴奋的双相作用。结果表明，PCT在急性治疗中产生镇静作用，而在连续治疗一周后产生兴奋作用。PCT在急性治疗中的镇静机制可能是由于血清素能活性增加和多巴胺能活性降低。然而，PCT在连续治疗一周后的兴奋机制可能涉及多巴胺能活性增加和血清素能活性降低。
