三黄泻心汤对大鼠中枢单胺能和γ-氨基丁酸能系统的影响。

Effects of san-huang-hsieh-hsin-tang on central monoaminergic and GABAergic systems in rats.

作者信息

Chu C Y, Chen H C, Shiow S J, Yen K Y, Hsieh M T

机构信息

Department of Biochemistry, Chung Shan Medical and Dental College, Taichung, Taiwan.

出版信息

Am J Chin Med. 1988;16(1-2):57-66. doi: 10.1142/S0192415X88000091.

DOI:10.1142/S0192415X88000091

PMID:3218632

Abstract

In this paper, the effects of San-Huang-Hsieh-Hsin-Tang on central monoaminergic and GABAergic systems were studied in rats. It was found that San-Huang-Hsieh-Hsin-Tang significantly (1) prolonged the period from the onset of clonic to tonic convulsions induced by picrotoxin, (2) prolonged the sleep duration induced by hexobarbital, (3) inhibited central catecholaminergic activity, (4) promoted central GABAergic activity, and (5) decreased the turnovers of central norepinephrine and dopamine.

摘要

本文研究了三黄泻心汤对大鼠中枢单胺能和γ-氨基丁酸能系统的影响。发现三黄泻心汤能显著：（1）延长由印防己毒素诱发的阵挛性惊厥至强直性惊厥的时间；（2）延长由己巴比妥诱导的睡眠时间；（3）抑制中枢儿茶酚胺能活性；（4）促进中枢γ-氨基丁酸能活性；（5）降低中枢去甲肾上腺素和多巴胺的更新率。