Distler P, Holt P R
Division of Gastroenterology, St. Luke's-Roosevelt Hospital Center, New York, N.Y. 10025, USA.
Dig Dis. 1997 Jul-Oct;15(4-5):302-11. doi: 10.1159/000171605.
Cancer of left and right colon has a differing prevalence at varying ages, in high- and low-incidence nations, as well as in men and in women. There also is a difference in clinical presentation, in prognosis, and possibly in genetic and environmental epidemiology. This review proposes that cancers of proximal and distal colon are different tumors because of their embryologic origin, genetic changes, and biologic identity. These factors are important in understanding the 'shift of tumors from more distal to more proximal sites in the colon' and in evaluating potential suggestions for instituting advances in diagnosis and prevention.
左半结肠和右半结肠癌症在不同年龄、高发病率和低发病率国家以及男性和女性中的患病率有所不同。在临床表现、预后方面也存在差异，在遗传和环境流行病学方面可能也有所不同。本综述提出，近端结肠和远端结肠癌症是不同的肿瘤，因为它们的胚胎起源、基因变化和生物学特性不同。这些因素对于理解“肿瘤在结肠中从更远端部位向更近端部位转移”以及评估推进诊断和预防方面的潜在建议非常重要。
