Hamir A N, Hanlon C A, Rupprecht C E
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square 19348, USA.
J Wildl Dis. 1996 Oct;32(4):670-3. doi: 10.7589/0090-3558-32.4.670.
A case of lymphosarcoma in a captive adult female raccoon (Procyon lotor) from northeastern Pennsylvania (USA) was observed in 1991. Prior to its death the raccoon had lost weight. At necropsy the carcass was in poor body condition and had pale mucous membranes. The thoracic and abdominal lymph nodes were enlarged, soft, and pale tan. Microscopically, there was effacement of normal lymph node architecture by sheets of mononuclear cells. These were well-differentiated small lymphocytes with distinct cell borders. Nuclei of these cells were darkly stained and mitotic figures were frequently seen. Similar but lesser numbers of neoplastic cells were seen in the parenchyma of liver, spleen, and the pancreas. Since the neoplasm involved several organs, we propose that the condition was of multicentric origin. Gross lesions, histopathologic findings and the organs involved differed from a previously described case of lymphosarcoma in a raccoon.
1991年，在美国宾夕法尼亚州东北部一只圈养的成年雌性浣熊（北美浣熊）身上观察到一例淋巴肉瘤病例。在死亡前，这只浣熊体重减轻。尸检时，尸体状况不佳，粘膜苍白。胸腹部淋巴结肿大、柔软，呈淡褐色。显微镜下，正常淋巴结结构被成片的单核细胞取代。这些是分化良好的小淋巴细胞，细胞边界清晰。这些细胞的细胞核染色深，可见频繁的有丝分裂象。在肝、脾和胰腺实质中也可见到数量较少但类似的肿瘤细胞。由于肿瘤累及多个器官，我们认为这种情况是多中心起源的。大体病变、组织病理学发现以及受累器官与先前描述的浣熊淋巴肉瘤病例不同。
