Glanz B I, Slonim D, Urowitz M B, Gladman D D, Gough J, MacKinnon A
Department of Psychology, Wellesley Hospital, Toronto, Ontario, Canada.
Neuropsychiatry Neuropsychol Behav Neurol. 1997 Oct;10(4):232-8.
The pattern of neuropsychological dysfunction in patients with inactive systemic lupus erythematosus (SLE) was examined. Fifty-eight subjects with inactive SLE and 47 healthy controls were administered a standardized neuropsychological test battery. Summary scores reflecting 18 different cognitive processes were derived. Subjects were designated cognitively impaired if three or more summary scores differed significantly from premorbid estimates of cognitive functioning. Cognitive impairment was identified in 43% of subjects with inactive SLE and 19% of healthy controls. Subjects with inactive SLE, as a group, performed significantly worse than healthy controls on measures of auditory verbal memory, visual spatial memory, psychomotor speed, and motor functioning. A significantly greater proportion of subjects with inactive SLE than healthy controls was impaired only on a measure of visual spatial memory. Cognitive impairment in subjects with inactive SLE was associated with increasing age. There were no associations between cognitive impairment and current depressive symptoms or current corticosteroid use. These findings suggest that cognitive dysfunction occurs frequently in inactive SLE. The variability of performance of subjects with inactive SLE is consistent with the heterogeneity of CNS involvement in the disease.
对非活动性系统性红斑狼疮（SLE）患者的神经心理功能障碍模式进行了研究。对58名非活动性SLE患者和47名健康对照者进行了标准化的神经心理测试组。得出了反映18种不同认知过程的综合分数。如果三个或更多综合分数与病前认知功能估计值有显著差异，则受试者被认定为认知受损。在43%的非活动性SLE患者和19%的健康对照者中发现了认知障碍。作为一个群体，非活动性SLE患者在听觉言语记忆、视觉空间记忆、心理运动速度和运动功能测量方面的表现明显比健康对照者差。与健康对照者相比，非活动性SLE患者中仅在视觉空间记忆测量方面受损的比例明显更高。非活动性SLE患者的认知障碍与年龄增长有关。认知障碍与当前的抑郁症状或当前使用皮质类固醇之间没有关联。这些发现表明，认知功能障碍在非活动性SLE中经常发生。非活动性SLE患者表现的变异性与该疾病中枢神经系统受累的异质性一致。
