MRC Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom.
The UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Front Immunol. 2018 Jun 6;9:1146. doi: 10.3389/fimmu.2018.01146. eCollection 2018.
The brain and nervous system are important targets for immune-mediated damage in systemic lupus erythematosus (SLE), resulting in a complex spectrum of neurological syndromes. Defining nervous system disease in lupus poses significant challenges. Among the difficulties to be addressed are a diversity of clinical manifestations and a lack of understanding of their mechanistic basis. However, despite these challenges, progress has been made in the identification of pathways which contribute to neurological disease in SLE. Understanding the molecular pathogenesis of neurological disease in lupus will inform both classification and approaches to clinical trials.
大脑和神经系统是系统性红斑狼疮（SLE）中免疫介导损伤的重要靶标，导致一系列复杂的神经综合征。定义狼疮中的神经系统疾病具有重大挑战。其中包括临床表现的多样性和对其机制基础的认识不足。尽管存在这些挑战，但在确定导致 SLE 神经病变的途径方面已取得进展。了解狼疮神经病变的分子发病机制将为分类和临床试验方法提供信息。
