水溶性自由基作为电子顺磁共振成像中的生物响应剂。

Water soluble free radicals as biologically responsive agents in electron paramagnetic resonance imaging.

作者信息

Sotgiu A, Colacicchi S, Placidi G, Alecci M

机构信息

INFM, c/o Department of Science and Biomedical Technology, University of L'Aquila, Italy.

出版信息

Cell Mol Biol (Noisy-le-grand). 1997 Sep;43(6):813-23.

PMID:9359628

Abstract

Electron paramagnetic resonance imaging (EPRI) is currently being developed at frequencies between 200 MHz and 2 GHz. EPRI can map the in vivo distribution of paramagnetic species, such as water soluble free radicals; nitroxide free radicals are commonly used. EPR images reflect the complexity of metabolic actions on the exogenous delivered nitroxides. Their reduction rate in vivo is affected by parameters such as oxygen concentration, pH and biodistribution. This paper illustrates the main features of low frequency EPRI and reconstruction techniques. Examples of EPR imaging, such as two-dimensional (2D) spatial mapping of the distribution of a nitroxide free radical in phantoms and in whole rat, are given.

摘要

电子顺磁共振成像（EPRI）目前正在200兆赫兹至2吉赫兹的频率范围内进行研发。EPRI能够绘制顺磁物质在体内的分布情况，比如水溶性自由基；通常使用的是氮氧自由基。EPR图像反映了对外源性递送的氮氧自由基进行代谢作用的复杂性。它们在体内的还原速率受氧气浓度、pH值和生物分布等参数的影响。本文阐述了低频EPRI的主要特征及重建技术。给出了EPR成像的实例，比如在模型和整个大鼠体内对氮氧自由基分布进行的二维（2D）空间映射。