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Insulin-like growth factor-binding protein-1 in human follicular fluid: a marker for oocyte maturation.

作者信息

Kawano Y, Narahara H, Matsui N, Nasu K, Miyamura K, Miyakawa I

机构信息

Department of Obstetrics and Gynecology, Oita Medical University, Japan.

出版信息

Gynecol Obstet Invest. 1997;44(3):145-8. doi: 10.1159/000291507.

DOI:10.1159/000291507
PMID:9359637
Abstract

In order to investigate the role of insulin-like growth factors (IGFs) in human ovulation, we evaluated the concentrations of IGF-binding proteins (IGFBPs) in human follicular fluid (FF). The concentrations of IGFBP-1 in the FFs of 15 women undergoing in vitro fertilization and embryo transfer were measured and related to those of 17beta-estradiol (E2), progesterone and androstenedione in the FFs. IGFBP-1 levels in the FFs were positively correlated with those of E2 and progesterone. No correlation was found between the IGFBP-1 and androstenedione levels in FFs. The concentrations of IGFBP-1 were significantly increased in the FFs which contained mature oocytes compared with those of immature oocytes, whereas IGFBP-3 in FFs tended to decrease as oocytes matured. It is suggested that IGFs may play important roles in human preovulatory processes, and that IGFBP-1 may be a valuable biochemical marker in the evaluation of oocytes.

摘要

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