Obstetrics and Gynecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70121 Bari, Italy.
IVF Center, Momo Fertilife, 76011 Bisceglie, Italy.
Int J Mol Sci. 2024 Nov 13;25(22):12197. doi: 10.3390/ijms252212197.
The elucidation of oocyte maturation mechanisms is paramount for advancing embryo development within the scope of assisted reproductive technologies (ART). Both cytoplasmic and nuclear maturation represent intricate processes governed by tightly regulated cellular pathways, which are essential for ensuring the oocyte's competence for fertilization and subsequent embryogenesis. A comprehensive grasp of these mechanisms is vital, as the maturation stage of the oocyte significantly influences chromosomal integrity, spindle formation, and its ability to support the initial stages of embryonic development. By leveraging this knowledge, we can enhance in vitro fertilization (IVF) protocols, refining ovarian stimulation regimens and culture conditions to improve oocyte quality. This, in turn, has the potential to boost pregnancy rates and outcomes. Further research in this area will contribute to the development of novel interventions that aim to increase the efficacy of preimplantation embryonic development, offering new opportunities for individuals undergoing fertility treatments.
阐明卵母细胞成熟机制对于在辅助生殖技术（ART）范围内推进胚胎发育至关重要。细胞质和核成熟都是由严格调控的细胞途径控制的复杂过程，对于确保卵母细胞受精和随后胚胎发生的能力至关重要。全面了解这些机制至关重要，因为卵母细胞的成熟阶段显著影响染色体完整性、纺锤体形成以及支持胚胎发育初始阶段的能力。通过利用这些知识，我们可以改进体外受精（IVF）方案，优化卵巢刺激方案和培养条件，以提高卵母细胞质量。这反过来又有可能提高妊娠率和妊娠结局。该领域的进一步研究将有助于开发旨在提高着床前胚胎发育效率的新干预措施，为接受生育治疗的个体提供新的机会。
