Bajjoka I, Patel T, O'Sullivan T
Department of Pharmacy Practice, Wayne State University, Detroit, MI, USA.
Ann Emerg Med. 1997 Nov;30(5):698-700. doi: 10.1016/s0196-0644(97)70091-x.
Risperidone is an antipsychotic drug used for the treatment of schizophrenia. It was expected that this atypical neuroleptic agent would not cause dystonia or neuroleptic malignant syndrome (NMS) owing to its unique mechanism of action with attenuated anti-dopaminergic activity and more potent antiserotoninergic activity. We report the case of a geriatric patient in whom signs and symptoms consistent with NMS developed after 3 weeks of risperidone therapy. The patient presented with fever, mental status changes, tremor, and rigidity. His laboratory findings were significant for increased serum creatine phosphokinase, hypernatremia, and metabolic acidosis. There have been few reported cases of risperidone-induced NMS. Health care providers should be aware of the risk of risperidone-induced NMS.
利培酮是一种用于治疗精神分裂症的抗精神病药物。由于其独特的作用机制，抗多巴胺能活性减弱且抗血清素能活性更强，预计这种非典型抗精神病药物不会引起肌张力障碍或抗精神病药物恶性综合征（NMS）。我们报告了一例老年患者的病例，该患者在接受利培酮治疗3周后出现了与NMS一致的体征和症状。患者表现为发热、精神状态改变、震颤和强直。他的实验室检查结果显示血清肌酸磷酸激酶升高、高钠血症和代谢性酸中毒。利培酮诱发NMS的报道病例很少。医疗保健提供者应意识到利培酮诱发NMS的风险。
