Takeshima Y, Yoneda K, Sanda N, Inai K
Second Department of Pathology, Hiroshima University School of Medicine, Japan.
Pathol Int. 1997 Oct;47(10):713-7. doi: 10.1111/j.1440-1827.1997.tb04447.x.
A case of solitary fibrous tumor of the prostate is reported. A 42-year-old man had been complaining of difficult voiding and constipation for 8 years. Urological and radiological examinations showed a large prostatic mass, and a total cystectomy and prostatectomy were performed. The tumor was 14 x 13 x 11 cm in size, solid with a fibromuscular capsule, and gray-tan in color. Histologically, the tumor was composed of short spindle-shaped and polygonal cells with mild to moderate nuclear atypia, predominantly arranged in the so-called 'patternless pattern' in a fibrocollagenous background. Mitoses were occasionally seen. Vascular invasion was also observed. Immunohistochemically, these cells were strongly positive for CD34 and vimentin, and occasionally for desmin. The maximum Ki-67 labeling index of the tumor cells was 4.5%. These findings are consistent with a solitary fibrous tumor. To our knowledge, this is the first report of a solitary fibrous tumor of the prostate in the English medical literature.
报告了一例前列腺孤立性纤维瘤病例。一名42岁男性因排尿困难和便秘8年就诊。泌尿外科和影像学检查显示前列腺有一巨大肿块，遂行全膀胱切除术及前列腺切除术。肿瘤大小为14×13×11cm，质地坚实，有纤维肌性包膜，呈灰棕色。组织学上，肿瘤由短梭形和多角形细胞组成，核异型性轻度至中度，主要在纤维胶原背景中呈所谓的“无模式模式”排列。偶尔可见核分裂象。还观察到血管侵犯。免疫组化显示，这些细胞CD34和波形蛋白呈强阳性，偶尔结蛋白也呈阳性。肿瘤细胞的最大Ki-67标记指数为4.5%。这些发现符合孤立性纤维瘤。据我们所知，这是英文医学文献中关于前列腺孤立性纤维瘤的首例报告。
