Slyper A H, Zvereva S, Schectman G, Hoffmann R G, Mueller R A, Walker J A
Medical College of Wisconsin, Milwaukee, USA.
Metabolism. 1997 Nov;46(11):1275-80. doi: 10.1016/s0026-0495(97)90230-4.
The relationship between low-density lipoprotein (LDL) peak particle diameter and insulin sensitivity, very-low-density lipoprotein (VLDL) + intermediate-density lipoprotein (LDL) triglyceride, cholesterol, and apoprotein B, postprandial lipemia, and LDL + high-density lipoprotein (HDL) triglyceride was assessed. The subjects were 101 healthy males aged 15 to 45 years. Sixty-one subjects (60.4%) were offspring of a parent with coronary artery disease before age 60, and 40 subjects (39.6%) had no parental history of coronary artery disease. LDL peak particle diameter was measured following polyacrylamide gradient gel electrophoresis. An insulin sensitivity index (Si) was determined from a frequently sampled intravenous glucose tolerance test using a minimal modeling method. A fat tolerance test was performed with a test meal containing 70 g/m2 fat, with triglyceride concentrations measured hourly for 12 hours. LDL peak particle diameter was significantly correlated with body mass index (BMI) (r = -.282, P < .01), waist to hip ratio (r = -.291, P < .01), fasting triglyceride (logarithmically [log] transformed) (r = -.566, P < .001), area under the postprandial triglyceride curve (log transformed) (r = -.562, P < .001), VLDL + IDL triglyceride (log transformed) (r = -.462, P < .001), VLDL + IDL cholesterol (log transformed) (r = -.477, P < .001), VLDL + IDL apoprotein B (log transformed) (r = -.321, P < .001), LDL + HDL triglyceride (log transformed) (r = .583, P < .001), and HDL cholesterol (r = .347, P < .001), but there was no significant correlation with Si. Using stepwise regression analysis, LDL + HDL triglyceride showed the strongest relationship to LDL peak particle diameter, accounting for 34% of the variation in size. Si was not an independent predictor of LDL particle size. In conclusion, insulin sensitivity appears to have little influence on LDL particle size. The importance of LDL + HDL triglyceride should be considered a preliminary finding warranting verification in this and other populations.
评估了低密度脂蛋白（LDL）峰值颗粒直径与胰岛素敏感性、极低密度脂蛋白（VLDL）+中间密度脂蛋白（IDL）甘油三酯、胆固醇、载脂蛋白B、餐后血脂以及LDL+高密度脂蛋白（HDL）甘油三酯之间的关系。研究对象为101名年龄在15至45岁之间的健康男性。其中61名受试者（60.4%）是60岁前患有冠状动脉疾病的父母的后代，40名受试者（39.6%）没有父母患冠状动脉疾病的家族史。采用聚丙烯酰胺梯度凝胶电泳法测量LDL峰值颗粒直径。使用最小模型法通过频繁采样的静脉葡萄糖耐量试验确定胰岛素敏感性指数（Si）。用含有70 g/m²脂肪的试验餐进行脂肪耐量试验，每小时测量一次甘油三酯浓度，共测量12小时。LDL峰值颗粒直径与体重指数（BMI）显著相关（r = -0.282，P < 0.01）、腰臀比（r = -0.291，P < 0.01）、空腹甘油三酯（对数[log]转换）（r = -0.566，P < 0.001）、餐后甘油三酯曲线下面积（对数转换）（r = -0.562，P < 0.001）、VLDL+IDL甘油三酯（对数转换）（r = -0.462，P < 0.001）、VLDL+IDL胆固醇（对数转换）（r = -0.477，P < 0.001）、VLDL+IDL载脂蛋白B（对数转换）（r = -0.321，P < 0.001）、LDL+HDL甘油三酯（对数转换）（r = 0.583，P < 0.001）以及HDL胆固醇（r = 0.347，P < 0.001），但与Si无显著相关性。通过逐步回归分析，LDL+HDL甘油三酯与LDL峰值颗粒直径的关系最为密切，占大小变异的34%。Si不是LDL颗粒大小的独立预测因子。总之，胰岛素敏感性似乎对LDL颗粒大小影响很小。LDL+HDL甘油三酯的重要性应被视为一项初步发现，有待在本群体及其他群体中进行验证。
