Nakamura N, Momoi Y, Watari T, Yoshino T, Tsujimoto H, Hasegawa A
Department of Veterinary Internal Medicine, Faculty of Agriculture, University of Tokyo, Japan.
J Vet Med Sci. 1997 Oct;59(10):957-60. doi: 10.1292/jvms.59.957.
Plasma thymidine kinase (TK) activity was evaluated as a plasma marker for canine lymphoma and leukemia. A tentative "cut-off" value was set at 6.0 U/l as the upper level of plasma TK based on the mean + 2SD of plasma TK activity in 13 clinically healthy dogs. The levels of plasma TK activity in all of the 20 dogs with lymphoma and leukemia were higher than the cut-off value, whereas those in dogs with lymphoma decreased in parallel with the reduction of the tumor mass after chemotherapy. These findings suggested that estimation of plasma TK activity can be used as a plasma marker for lymphoma and leukemia in the dog.
血浆胸苷激酶（TK）活性被评估为犬淋巴瘤和白血病的一种血浆标志物。基于13只临床健康犬血浆TK活性的均值 + 2标准差，暂定血浆TK的“临界”值设定为6.0 U/l作为血浆TK的上限水平。20只患有淋巴瘤和白血病的犬的血浆TK活性水平均高于临界值，而患有淋巴瘤的犬在化疗后血浆TK活性水平随肿瘤肿块的缩小而平行下降。这些发现表明，血浆TK活性的评估可作为犬淋巴瘤和白血病的一种血浆标志物。
