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Sequence analysis of functional regions of homoserine dehydrogenase genes from L-lysine and L-threonine-producing mutants of Brevibacterium lactofermentum.

作者信息

Sugimoto M, Tanaka A, Suzuki T, Matsui H, Nakamori S, Takagi H

机构信息

Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.

出版信息

Biosci Biotechnol Biochem. 1997 Oct;61(10):1760-2. doi: 10.1271/bbb.61.1760.

DOI:10.1271/bbb.61.1760
PMID:9362124
Abstract

The homoserine dehydrogenase (HD) genes from Brevibacterium lactofermentum lysine- and threonine-producing mutants were cloned, using the polymerase chain reaction, and sequenced. We found the amino acid substitutions, Val104Ile in the lysine-producing mutants in which HD may cause leaky mutation and Ser393Phe in the threonine-producing mutant with feedback-insensitive HD.

摘要

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