Ridding M C, Rothwell J C
MRC Human Movement and Balance Unit, Institute of Neurology, London, UK.
Electroencephalogr Clin Neurophysiol. 1997 Oct;105(5):340-4. doi: 10.1016/s0924-980x(97)00041-6.
We investigated whether input/output curves of human motor cortex could provide similar information to cortical mapping under two conditions where the motor maps are known to change dramatically: ischaemic anaesthesia and amputation. Stimulus/response curves were constructed by recording the size of EMG responses evoked in arm muscles with transcranial magnetic stimulation at a single site using a range of intensities. Changes in the slope of this relationship during ischaemic anaesthesia (6 normal subjects) or amputation (two patients) were compared to changes in cortical motor maps produced by stimulating different sites at the same intensity. At rest both interventions increased map areas, as well as the slope of the stimulus/response curves. During voluntary activity they had no effect. We conclude that stimulus/response curves can detect changes in cortical motor maps, and discuss potential mechanisms for this effect.
我们研究了在运动图谱已知会发生显著变化的两种情况下，即缺血性麻醉和截肢时，人类运动皮层的输入/输出曲线是否能提供与皮层映射类似的信息。刺激/反应曲线是通过在单个部位使用一系列强度的经颅磁刺激记录手臂肌肉中诱发的肌电图反应大小来构建的。将缺血性麻醉（6名正常受试者）或截肢（两名患者）期间这种关系斜率的变化与以相同强度刺激不同部位所产生的皮层运动图谱变化进行比较。在静息状态下，两种干预措施都会增加图谱面积以及刺激/反应曲线的斜率。在自主活动期间，它们没有影响。我们得出结论，刺激/反应曲线可以检测皮层运动图谱的变化，并讨论了这种效应的潜在机制。
