Hall M J, Bradley T D
Toronto Hospital (General Division), Ontario, Canada.
Curr Opin Pulm Med. 1995 Nov;1(6):512-8. doi: 10.1097/00063198-199511000-00014.
A number of novel and important observations have recently arisen that emphasize the interaction between sleep apnea and cardiovascular function. New evidence of a role for obstructive sleep apnea as an independent factor in the genesis of hypertension and nocturnal myocardial ischemia has been described. Advances have been made in the understanding of the acute impact of sleep-disordered breathing on hemodynamic function, and a better understanding of the interaction between sleep-disordered breathing and congestive heart failure is now emerging. There is now strong evidence that reversal of sleep-related breathing disorders by nasal continuous positive airway pressure leads to improvements in markers of cardiovascular outcome in selected patients with congestive heart failure. These findings augur well for the development of new diagnostic approaches and treatment strategies for patients with sleep apnea and coexisting cardiovascular disease.
最近出现了一些新颖且重要的观察结果，这些结果强调了睡眠呼吸暂停与心血管功能之间的相互作用。已有关于阻塞性睡眠呼吸暂停作为高血压和夜间心肌缺血发生的独立因素的新证据。在理解睡眠呼吸紊乱对血流动力学功能的急性影响方面取得了进展，并且目前对睡眠呼吸紊乱与充血性心力衰竭之间的相互作用有了更好的理解。现在有强有力的证据表明，经鼻持续气道正压通气纠正与睡眠相关的呼吸障碍可使部分充血性心力衰竭患者的心血管结局指标得到改善。这些发现为睡眠呼吸暂停合并心血管疾病患者新诊断方法和治疗策略的开发带来了良好的前景。
