al-Nuaim A R, Mirdad S, al-Rubeaan K, al-Mazrou Y, al-Attas O, al-Daghari N, Khoja T
King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Int J Cardiol. 1997 Oct 31;62(1):47-54. doi: 10.1016/s0167-5273(97)00164-2.
To study the characteristics of risk factors for hypercholesterolemia among the Saudi population.
Population-based cross-sectional national epidemiological randomized household survey.
4548 Saudi subjects, aged 15 years and above. Sample was representative and in accordance with the national population distribution with respect to age, gender, regional and residency, urban vs. rural, population distribution.
Height and weight with calculation of body mass index, blood samples were drawn and assayed for glucose and total cholesterol concentration. Hypercholesterolemia (HC) was defined: borderline high HC (5.2-6.2 mmol l-1) and high HC (> 6.2 mmol l-1). Univariate, multivariate, simple logistic, multiple logistic, odd ratio and chi-square were employed in the statistical analysis.
The risk of developing HC increased with age by 2% and 1% for each year increase in age for borderline high HC and high HC. The risk of developing HC was significantly higher among female subjects. There was no significant relation between the spectrum of BMI group, underweight to obesity, with risk of developing borderline high or high HC. There was a significant increase in the risk of developing HC among residents of urban communities. There was no significant regional variation for risk of borderline high HC, however, there was a significant increase in the risk of developing high HC among residents of Central and Eastern regions, compared with other regions.
The characteristics of risk factors for HC among the Saudi population differ in many respects from other populations. Overweight and obesity are not significant risk factors for HC. Rural communities are more at risk of HC than urban communities. The population of the Eastern and Central regions were at significantly higher risk of developing HC. The relatively recent urbanization may account for the low prevalence of HC. It may partially explain the dissociation between obesity and HC. Food habits, both in quantity and quality in rural communities in genetically predisposed homogenous populations may account for the increase in the prevalence of HC in rural communities. There is a need to propagate information about the potential health hazard of obesity and HC among Saudi communities, at large, and specifically in the Eastern and Central regions. There is a need to study the food patterns of rural communities which may explain partially the relative increase in the prevalence of HC in rural communities.
研究沙特人群中高胆固醇血症的危险因素特征。
基于人群的横断面全国流行病学随机家庭调查。
4548名15岁及以上的沙特受试者。样本具有代表性，在年龄、性别、地区和居住情况、城乡分布、人口分布方面符合全国人口分布。
测量身高和体重并计算体重指数，采集血样检测血糖和总胆固醇浓度。高胆固醇血症（HC）定义为：临界高HC（5.2 - 6.2毫摩尔/升）和高HC（> 6.2毫摩尔/升）。统计分析采用单变量、多变量、简单逻辑回归、多重逻辑回归、比值比和卡方检验。
临界高HC和高HC的患病风险随年龄增长而增加，年龄每增加一岁，临界高HC和高HC的患病风险分别增加2%和1%。女性受试者患HC的风险显著更高。体重指数组范围（从体重过轻到肥胖）与患临界高HC或高HC的风险之间无显著关系。城市社区居民患HC的风险显著增加。临界高HC的风险在地区上无显著差异，然而，与其他地区相比，中部和东部地区居民患高HC的风险显著增加。
沙特人群中HC的危险因素特征在许多方面与其他人群不同。超重和肥胖不是HC的显著危险因素。农村社区患HC的风险比城市社区更高。东部和中部地区的人群患HC的风险显著更高。相对较新的城市化进程可能是HC患病率低的原因。这可能部分解释了肥胖与HC之间的分离现象。在遗传易感性相同的农村社区，饮食习惯在数量和质量上的差异可能是农村社区HC患病率增加的原因。有必要在沙特社区，尤其是东部和中部地区，广泛传播关于肥胖和HC潜在健康危害的信息。有必要研究农村社区的饮食模式，这可能部分解释农村社区HC患病率相对增加的原因。
