Hiraoka M, Saito I, Tsubota K, Sugai S, Miyasaka N
Division of Immunological Diseases, Tokyo Medical and Dental University, Japan.
Jpn J Ophthalmol. 1997 Sep-Oct;41(5):312-8. doi: 10.1016/s0021-5155(97)00072-5.
We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjögren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the normal lacrimal gland, suggesting that the CD44 v6 variant exon may be closely associated with the development of LPD in Sjögren's syndrome.
我们研究了CD44亚型在一名患有单侧泪腺淋巴增殖性疾病（LPD）的干燥综合征患者泪腺LPD中的作用。在患有LPD的泪腺浸润淋巴细胞中选择性检测到含有v6外显子的CD44变体，但在正常泪腺浸润淋巴细胞中未检测到，这表明CD44 v6变体外显子可能与干燥综合征中LPD的发生密切相关。
