Schmidt J D, Gibbons R P, Johnson D E, Prout G R, Scott W W, Murphy G P
Urology. 1976 Jun;7(6):602-10. doi: 10.1016/0090-4295(76)90085-6.
A total of 125 patients with progressing advanced prostatic cancer were entered into a chemotherapy study comparing cyclophosphamide, 5-fluorouracil, and standard therapy. Parameters of response were studied in 110 patients who could be evaluated. Thirty-six patients (33 per cent) were considered to have an objective response, that is becoming stable (29 patients) or in partial regression (7 patients). Negative response parameters (predictors of a poor response to chemotherapy or standard theraphy leading to progress) included (1) bone marrow evidence of prostatic cancer, (2) abnormal liver scan, (3) prior radiation therapy (indirectly through increased toxicity to chemotherapy), and (4) lack of bilateral orchiectomy prior to randomization. Positive indicators (predictors of good responses) included (1) reduction of primary tumor mass, especially after administration of 5-fluorouracil or cyclophosphamide, and (2) hemoglobin values. There were more objective responders to cyclophosphamide than standard therapy whether the hemoglobin was initially normal or low. Indeterminate parameters of response included weight gain, presence of bony or soft tissue metastases, relief of pain, performance status, excretory urography, and biochemical determinations of liver and renal function.
共有125例进展期前列腺癌患者进入一项比较环磷酰胺、5-氟尿嘧啶和标准疗法的化疗研究。对110例可评估的患者进行了反应参数研究。36例患者（33%）被认为有客观反应，即病情稳定（29例）或部分缓解（7例）。阴性反应参数（化疗或标准疗法反应不佳导致病情进展的预测指标）包括：（1）前列腺癌的骨髓证据；（2）肝脏扫描异常；（3）既往放疗史（通过增加化疗毒性间接导致）；（4）随机分组前未行双侧睾丸切除术。阳性指标（良好反应的预测指标）包括：（1）原发肿瘤肿块缩小，尤其是在使用5-氟尿嘧啶或环磷酰胺后；（2）血红蛋白值。无论血红蛋白最初正常还是偏低，环磷酰胺组的客观反应者均多于标准疗法组。反应的不确定参数包括体重增加、骨或软组织转移的存在、疼痛缓解、身体状况、排泄性尿路造影以及肝脏和肾功能的生化测定。
