一名意义未明单克隆丙种球蛋白病患者体内的一种新型细胞周期依赖性抗核抗体。

A novel cell cycle-dependent antinuclear antibody in a patient with a monoclonal gammopathy of unknown significance.

作者信息

Zuber M, Pfreundschuh M, Sörensen H

机构信息

University of Saarland Medical Center, Internal Medicine I, Homburg D-66421, Germany.

出版信息

Eur J Med Res. 1996 Apr 18;1(7):349-54.

PMID:9364038

Abstract

A patient with a monoclonal gammopathy, an erosive polyarthritis and a spastic paraparesis of both legs revealed a high titer of antinuclear antibodies with an immunofluorescence pattern hitherto unknown. A pleomorphic staining pattern of unsynchronized cells suggested a cell cycle-dependent autoantigen. Cell cycle-dependency of the antigen was confirmed by staining tissue sections, serum-starvation of tissue culture cells and mitogen-stimulation of peripheral blood lymphocytes. The antinuclear antibody does not belong to the paraprotein fraction of the serum immunoglobulins.

摘要

一名患有单克隆丙种球蛋白病、侵蚀性多关节炎和双腿痉挛性截瘫的患者，其抗核抗体滴度很高，免疫荧光模式迄今未知。未同步化细胞的多形性染色模式提示存在细胞周期依赖性自身抗原。通过对组织切片染色、使组织培养细胞血清饥饿以及用丝裂原刺激外周血淋巴细胞，证实了该抗原的细胞周期依赖性。抗核抗体不属于血清免疫球蛋白的副蛋白部分。