Vitali C, Baglioni P, Vivaldi I, Cacialli R, Tavoni A, Bombardieri S
Clinical Immunology Unit, University of Pisa, Italy.
Arthritis Rheum. 1991 Dec;34(12):1600-5. doi: 10.1002/art.1780341220.
We report 4 case histories in which an erosive arthritis was associated with the presence of a monoclonal gammopathy of uncertain significance. In all 4 cases, the appearance of paraprotein was noted either before or during the development of the arthritis. Two patients had a rather atypical oligoarthritis, while the others had a rheumatoid-like, symmetric polyarthritis. A synovial amyloid deposit was present in 2 patients, while mild mixed mononuclear infiltrates were the main pathologic finding in the others. In 2 patients, immunohistochemical investigation demonstrated deposits of immunoglobulin-derived material of the same isotype as the monoclonal component in the synovial tissue.
我们报告了4例病史，其中侵蚀性关节炎与意义未明的单克隆丙种球蛋白病相关。在所有4例中，在关节炎发生之前或期间均注意到副蛋白的出现。2例患者患有相当不典型的寡关节炎，而其他患者患有类风湿样对称性多关节炎。2例患者存在滑膜淀粉样沉积物，而其他患者的主要病理发现是轻度混合单核细胞浸润。在2例患者中，免疫组织化学研究表明滑膜组织中存在与单克隆成分同种型相同的免疫球蛋白衍生物质沉积物。
