Bravo H, Inzunza O, Fernández V, Sanhueza M
Deparatamento de Anatomía Escuela de Medicina Pontificia Universidad Católica de Chile, Santiago, Chile.
Neurosci Lett. 1997 Oct 3;234(2-3):103-6. doi: 10.1016/s0304-3940(97)00689-7.
The expression of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) was studied in the rat somatosensory cortex during postnatal development from day 6 to 120. Distribution of labeled neurons was quantified in dorso-medial and ventro-lateral aspects of the cortex, and correlated with known tridimensional gradients of histogenetic development and maturation of cortical neurons. NADPH positive neurons were non-pyramidal cells that in all developmental periods were more numerous in infragranular than in supragranular layers of the cortex. Additionally, more labeled cells were found in ventro-lateral than dorso-medial infragranular layers and in anterior than posterior aspects of the cerebral cortex. These patterns of distribution correlate well with the gradients of histogenetic development and with the pattern of maturation of cortical neurons.
在出生后6天至120天的大鼠体感皮层发育过程中，对烟酰胺腺嘌呤二核苷酸磷酸黄递酶（NADPH-d）的表达进行了研究。对皮层背内侧和腹外侧区域标记神经元的分布进行了量化，并与已知的皮层神经元组织发生发育和成熟的三维梯度相关联。NADPH阳性神经元为非锥体细胞，在所有发育阶段，其在皮层颗粒下层中的数量均多于颗粒上层。此外，在腹外侧颗粒下层中发现的标记细胞比背内侧颗粒下层多，在大脑皮层的前部比后部多。这些分布模式与组织发生发育梯度以及皮层神经元的成熟模式密切相关。
