Milon H, Baleydier A
Service de Cardiologie, Hôpital de la Croix Rousse, Lyon, France.
Therapie. 1997 May-Jun;52(3):195-205.
The antihypertensive and metabolic effects of lisinopril 20 mg/hydrochlorothiazide 12.5 mg in fixed combination were compared with those of captopril 50 mg/hydrochlorothiazide 25 mg in fixed combination in a double-blind clinical trial. After a 3-week placebo run-in period, two parallel groups of hypertensive patients (188 patients in total) each received one treatment once a day for 6 weeks. Blood pressure was measured with a mercury sphygmomanometer and on two occasions by 24 h ambulatory blood pressure monitoring (ABPM). Results indicate that both treatments have similar effects on casual blood pressure measurements, while ABPM recordings show that the lisinopril 20 mg/hydrochlorothiazide 12.5 mg combination is more effective during the last period of the dosing interval. Lisinopril 20 mg/hydrochlorothiazide 12.5 mg as combination antihypertensive treatment does not induce alterations in serum potassium and triglycerides.
在一项双盲临床试验中，对赖诺普利20毫克/氢氯噻嗪12.5毫克固定复方制剂与卡托普利50毫克/氢氯噻嗪25毫克固定复方制剂的降压和代谢作用进行了比较。经过3周的安慰剂导入期后，两组平行的高血压患者（共188例）每天各接受一次治疗，持续6周。使用汞柱式血压计测量血压，并通过24小时动态血压监测（ABPM）测量两次。结果表明，两种治疗对偶测血压的影响相似，而ABPM记录显示，赖诺普利20毫克/氢氯噻嗪12.5毫克复方制剂在给药间隔的最后阶段更有效。赖诺普利20毫克/氢氯噻嗪12.5毫克作为联合降压治疗不会引起血清钾和甘油三酯的改变。
