α1-抗胰蛋白酶缺乏男性的主动脉壁硬度变化
Changes in aortic wall stiffness in men with alpha 1-antitrypsin deficiency.
作者信息
Ahlgren A R, Piitulainen E, Sonesson B, Länne T
机构信息
Department of Clinical Physiology, University of Lund, Malmö University Hospital, Sweden.
出版信息
Eur J Vasc Endovasc Surg. 1997 Oct;14(4):252-7. doi: 10.1016/s1078-5884(97)80236-5.
OBJECTIVES
To examine the diameter and distensibility of the abdominal aorta in patients with severe alpha 1-antitrypsin deficiency, and to compare the results with those of normal subjects.
MATERIAL AND METHODS
Abdominal aortic diameter and stiffness (beta) was measured using echo-tracking sonography in 19 men (mean age 50, range 25-79) and 17 women (mean age 46, range 26-62) with severe alpha 2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender.
RESULTS
There was no significant difference in the abdominal aortic diameter between controls and patients with alpha 1-antitrypsin deficiency when corrected for age, sex and body surface area (men p = 0.20, women p = 0.10). Men with alpha 1-antitrypsin deficiency showed significantly lower stiffness in the abdominal aorta compared to controls (p = 0.025), whereas women did not (p = 0.17).
CONCLUSIONS
No significant difference in abdominal aortic diameter could be detected in patients with alpha 1-antitrypsin deficiency compared with controls. However, aortic distensibility in men with alpha 1-antitrypsin deficiency is altered. This may reflect early vessel wall abnormality.
目的
研究严重α1-抗胰蛋白酶缺乏症患者腹主动脉的直径和扩张性，并将结果与正常受试者进行比较。
材料与方法
使用回声跟踪超声检查对19名男性（平均年龄50岁，范围25 - 79岁）和17名女性（平均年龄46岁，范围26 - 62岁）的严重α2-抗胰蛋白酶缺乏症患者测量腹主动脉直径和僵硬度（β）。将结果与相应年龄和性别的健康个体进行比较。
结果
在校正年龄、性别和体表面积后，对照组与α1-抗胰蛋白酶缺乏症患者的腹主动脉直径无显著差异（男性p = 0.20，女性p = 0.10）。与对照组相比，α1-抗胰蛋白酶缺乏症男性的腹主动脉僵硬度显著降低（p = 0.025），而女性则无此差异（p = 0.17）。
结论
与对照组相比，未检测到α1-抗胰蛋白酶缺乏症患者的腹主动脉直径有显著差异。然而，α1-抗胰蛋白酶缺乏症男性的主动脉扩张性发生了改变。这可能反映了早期血管壁异常。
Zotero 插件