Podda M V, Deriu F, Solinas A, Demontis M P, Varoni M V, Spissu A, Anania V, Tolu E
Department of Biomedical Science, Section of Human Physiology, University of Sassari, Italy.
Pharmacol Res. 1997 Sep;36(3):199-202. doi: 10.1006/phrs.1997.0213.
The effect of atrazine oral administration on cerebellar forelimb projection area was studied in rats in vivo. Rats acutely treated with atrazine (100 mg kg-1, BW) showed a significant decrease in spontaneous Purkinje cell firing rate. Atrazine also decreased the cerebellar potentials evoked by electrical stimulation of the ipsilateral radial nerve, affecting mostly the response to climbing fiber input. These results demonstrate that atrazine exerts a toxic action on central nervous system. The effects on the cerebellar somatosensory cortex could be responsible for motor disorders frequently observed in animals intoxicated with atrazine.
在体内研究了大鼠口服阿特拉津对小脑前肢投射区的影响。急性给予阿特拉津（100 mg/kg体重）的大鼠，其浦肯野细胞自发放电频率显著降低。阿特拉津还降低了电刺激同侧桡神经诱发的小脑电位，主要影响对攀缘纤维输入的反应。这些结果表明，阿特拉津对中枢神经系统有毒性作用。对小脑体感皮层的影响可能是阿特拉津中毒动物中经常观察到的运动障碍的原因。
