Staib F, Grosse G, Mishra S K
Zentralbl Bakteriol Orig A. 1976 May;234(4):450-61.
During a certain period of the course of infection in white mice inoculated intraperitoneally with the pure culture of a proteolysing strain of Candida albicans, Staphylococcus aureus and C. albicans both, were isolated simultaneously from the peritoneal abscesses, especially those adhering to the stomach, duodenum, pancreas and the upper part of small intestine. This concommitant occurrence of the two pathogens was further corroborated by histopathological examination which revealed large number of staphylococci present in the close neighbourhood of Candida cells, usually in the center of the granulomata caused by the fungus. In view of the facts that the proteolytic end-products of C. albicans can offer a good substratum for the growth of S. aureus and the latter may be isolated from the intestinal tract of apparently healthy mice, possibly as a constituent of the transient microflora, the co-existence of these two important aetiologic agents of endogenous infections as encountered during this study appears to be of great clinical interest. Furthermore, these observations also demonstrate the importance of controlling the bacterial flora of mice for pure mycological studies.
在用白色念珠菌蛋白水解菌株的纯培养物腹腔接种的小白鼠感染过程中的某一时期，金黄色葡萄球菌和白色念珠菌同时从腹腔脓肿中分离出来，特别是那些附着于胃、十二指肠、胰腺和小肠上部的脓肿。组织病理学检查进一步证实了这两种病原体的同时出现，该检查显示在念珠菌细胞附近，通常是在由真菌引起的肉芽肿中心存在大量葡萄球菌。鉴于白色念珠菌的蛋白水解终产物可为金黄色葡萄球菌的生长提供良好的培养基，并且后者可能从看似健康的小鼠肠道中分离出来，可能作为短暂微生物群的一个组成部分，在本研究中遇到的这两种内源性感染的重要病原体的共存似乎具有重大的临床意义。此外，这些观察结果还证明了在进行纯真菌学研究时控制小鼠细菌菌群的重要性。
