Sahin U, Türeci O, Pfreundschuh M
Medizinische Klinik I, Universität des Saarlandes, Homburg, Germany.
Curr Opin Immunol. 1997 Oct;9(5):709-16. doi: 10.1016/s0952-7915(97)80053-2.
Using the antibody repertoire of cancer patients for the systematic search for human tumor antigens, a plenitude of new human tumor antigens has been identified demonstrating that many human tumors elicit multiple immune responses in the autologous host. The abundance of serologically defined human tumor antigens facilitates the identification of T cell dependent antigens and provides a basis for peptide and gene therapy vaccine strategies in a wide variety of human cancers.
利用癌症患者的抗体库系统搜索人类肿瘤抗原，已鉴定出大量新的人类肿瘤抗原，这表明许多人类肿瘤在自体宿主中引发多种免疫反应。血清学定义的人类肿瘤抗原丰富，有助于鉴定T细胞依赖性抗原，并为多种人类癌症的肽和基因治疗疫苗策略提供了基础。
