Schmitt H P
Acta Neuropathol. 1976 Jun 15;35(2):109-16. doi: 10.1007/BF00690557.
A man of 68, who died from a second heart stroke had neurogenic atrophy of the legs. The anterior tibial muscle showed abundant target and targetoid fibres. Half a year prior to death he had increasing weakness and wasting of the legs. The morphometric evaluation of the target and targetoid fibres showed a considerable independence of the plane size of the single zones from the total gauge of the fibres on cross section. Only a small part of the variation in size of zone 2 (4%) depended on the size of the target, indicating that zone 2 cannot just be a passive product of a shrinkage and disappearance of the target, but that there must be an active process, which leads to the change in zone 2. The regressive development of the centrally demarcated fibrillar bundle (target) is regarded as secondary degeneration following interruption of the nutritional supply.
一名68岁男性死于第二次心脏病发作，其腿部出现神经源性萎缩。胫前肌显示出丰富的靶形纤维和类靶形纤维。死亡前半年，他的腿部无力和消瘦情况日益加重。对靶形纤维和类靶形纤维的形态计量学评估显示，单个区域的平面大小与纤维横截面积的总量具有相当大的独立性。区域2大小变化中只有一小部分（4%）取决于靶形纤维的大小，这表明区域2不仅仅是靶形纤维收缩和消失的被动产物，而必定存在一个导致区域2发生变化的活跃过程。中央划定的纤维束（靶形纤维）的退行性发展被认为是营养供应中断后的继发性变性。
