Volk B
Acta Neuropathol. 1977 Apr 29;38(1):39-43. doi: 10.1007/BF00691274.
In a muscle biopsy from a patient suffering about 2 years from an amyotrophic lateral sclerosis groups of atrophic fibres and target fibres were observed. By electron microscopic examination, amongst numerous parallel or spinal cisternae near the plasma membrane, single-membrane bound smooth tubular elements with a constant diameter of 200-300 A occur in the central and intermediary zone of some target fibres. The connexion between these tubules and the terminal cisternae (triads) of the sarcoplasmic reticulum, suggest that this phenomenon seems to be a proliferation of the transversal-tubular system due to the partial denervation. Only a mechanical displacement of the T-tubules as a result of the destruction of the muscle fibres is not plausible, because the T-system volumetrically amounts only 0.3-0.5% of the muscle fibre.
在一名患有肌萎缩侧索硬化症约2年的患者的肌肉活检中，观察到了萎缩纤维群和靶纤维。通过电子显微镜检查，在靠近质膜的众多平行或脊髓池之间，一些靶纤维的中央和中间区域出现了直径恒定为200 - 300埃的单膜结合光滑管状元件。这些小管与肌浆网的终末池（三联体）之间的连接表明，这种现象似乎是由于部分去神经支配导致的横管系统的增殖。仅由于肌纤维破坏导致T小管的机械移位是不合理的，因为T系统在体积上仅占肌纤维的0.3 - 0.5%。
