Perea A, Viñambres C, Clemente F, Villanueva-Peñacarrillo M L, Valverde I
Department of Metabolism, Nutrition and Hormones, Foundación Jiménez Díaz, Madrid, Spain.
Horm Metab Res. 1997 Sep;29(9):417-21. doi: 10.1055/s-2007-979068.
In rat adipocytes, GLP-1 (7-36) amide induced an increment in 2-deoxy-glucose uptake, which was additive to that of insulin. Furthermore, in rat fat, GLP-1 (7-36) amide provoked a rise in glycogen synthesis, glucose oxidation and utilization and lipogenesis, the increments being lower than those obtained with insulin. These data support the idea that GLP-1 exerts insulin-like effects on glucose metabolism in rat adipose tissue, as it does in rat hepatocytes and skeletal muscle, although with a lower potency than that of insulin.
在大鼠脂肪细胞中，胰高血糖素样肽-1（7-36）酰胺可诱导2-脱氧葡萄糖摄取增加，且此增加与胰岛素诱导的增加具有相加作用。此外，在大鼠脂肪组织中，胰高血糖素样肽-1（7-36）酰胺可引起糖原合成、葡萄糖氧化与利用以及脂肪生成增加，但其增加幅度低于胰岛素所引起的增加幅度。这些数据支持以下观点：胰高血糖素样肽-1在大鼠脂肪组织中对葡萄糖代谢发挥类似胰岛素的作用，如同在大鼠肝细胞和骨骼肌中一样，尽管其效力低于胰岛素。
