Mansoor G A, White W B
Am J Kidney Dis. 1997 Nov;30(5):591-605. doi: 10.1016/s0272-6386(97)90483-2.
Hypertension is a key factor in the genesis and deterioration of many renal diseases and is also a risk factor for death in patients with end-stage renal disease. However, the standard methods of measurement are prone to variability, especially in patients undergoing dialysis. The technique of ambulatory blood pressure monitoring allows a better assessment of overall blood pressure levels and promises to assume a bigger role in the care of renal patients. Ambulatory blood pressure monitoring is widely used in hypertension trials, and the reports of several consensus meetings on the clinical uses of ambulatory blood pressure monitoring have been published. Two similar validation protocols now exist for ambulatory blood pressure monitors, and tables of population-based normal blood pressures for age and gender are available. The available evidence suggests that ambulatory blood pressure compared with blood pressure measured in the physician's office is better correlated to left ventricular mass in subjects with chronic renal disease. Furthermore, studies in subjects with chronic renal disease and those undergoing renal replacement therapy show that blood pressure control is suboptimal in many patients and that nocturnal blood pressure is generally higher than in control subjects. Further insights into overall blood pressure behavior in this population will certainly emerge in the future.
高血压是许多肾脏疾病发生和恶化的关键因素,也是终末期肾病患者死亡的危险因素。然而,标准测量方法容易出现变异性,尤其是在接受透析的患者中。动态血压监测技术能够更好地评估总体血压水平,并有望在肾病患者的护理中发挥更大作用。动态血压监测在高血压试验中广泛应用,关于动态血压监测临床应用的几次共识会议报告已经发表。目前有两种类似的动态血压监测仪验证方案,并且有按年龄和性别划分的基于人群的正常血压表。现有证据表明,与在医生办公室测量的血压相比,动态血压与慢性肾病患者的左心室质量相关性更好。此外,对慢性肾病患者和接受肾脏替代治疗患者的研究表明,许多患者的血压控制不理想,并且夜间血压通常高于对照组。未来肯定会对这一人群的总体血压行为有更深入的了解。