May F E, Westley B R
Department of Pathology, University of Newcastle upon Tyne, Royal Victoria Infirmary, U.K.
J Pathol. 1997 Sep;183(1):4-7. doi: 10.1002/(SICI)1096-9896(199709)183:1<4::AID-PATH1099>3.0.CO;2-5.
The three human trefoil proteins pS2, human intestinal trefoil factor (hITF), and human spasmolytic polypeptide (hSP) are expressed principally in the mucosa of the gastrointestinal tract. They are also expressed in a variety of other normal tissues and tumours. This review discusses the pattern of expression of trefoil proteins in cancer, current views on the biological functions of trefoil proteins, and the way in which the expression of trefoil proteins may influence the behaviour of cancer cells.
三种人三叶因子蛋白，即pS2、人肠三叶因子（hITF）和人解痉多肽（hSP），主要在胃肠道黏膜中表达。它们也在多种其他正常组织和肿瘤中表达。本文综述了三叶因子蛋白在癌症中的表达模式、关于三叶因子蛋白生物学功能的当前观点，以及三叶因子蛋白的表达可能影响癌细胞行为的方式。
