Ribieras S, Tomasetto C, Rio M C
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale U184, Université Louis Pasteur, Illkirch, C.U. de Strasbourg, France.
Biochim Biophys Acta. 1998 Aug 19;1378(1):F61-77. doi: 10.1016/s0304-419x(98)00016-x.
pS2/TFF1 trefoil factor is normally expressed in the stomach, and is found ectopically in gastrointestinal inflammatory disorders and in various carcinomas. It is involved in stomach ontogenesis and in the maintenance of the integrity of the mucosa, and may represent a pharmacological tool for prevention and healing of gastrointestinal ulcerations. In breast cancer, it can be used to select patients suitable for hormone therapy. pS2/TFF1 is a pleiotropic factor involved in mucin polymerization, cell motility, cell proliferation and/or differentiation, and possibly in the nervous system.
pS2/TFF1三叶因子通常在胃中表达，并在胃肠道炎症性疾病和各种癌症中异位表达。它参与胃的发生和黏膜完整性的维持，可能是预防和治疗胃肠道溃疡的一种药理学工具。在乳腺癌中，它可用于筛选适合激素治疗的患者。pS2/TFF1是一种多效性因子，参与黏蛋白聚合、细胞运动、细胞增殖和/或分化，可能还参与神经系统。
