Sadikot R T, Greene T, Meadows K, Arnold A G
Castle Hill Hospital, North Humberside, UK.
Thorax. 1997 Sep;52(9):805-9. doi: 10.1136/thx.52.9.805.
Primary spontaneous pneumothorax (PSP) is a common clinical problem and its incidence is thought to be increasing. The risk of recurrence is high and various studies quote rates of 20-60%. Factors which may or may not predispose to recurrence have not yet been established.
In a study period of four years 291 cases with a diagnosis of pneumothorax were reviewed; 153 patients with PSP were included in the study. Their risk of recurrence was analysed with particular reference to the following variables: age, sex, height and body mass index (BMI) of the patient, the initial size of pneumothorax, the smoking status of the patient, and the primary form of treatment employed. Univariate analysis was carried out by chi 2 testing and multivariate analysis was calculated by a logistic regression model.
A retrospective study of 275 episodes of PSP in 153 patients over a four year period confirmed a high incidence of recurrence (54.2%). PSP was twice as common in men as in women, though women were significantly more likely to develop a recurrence (chi 2 = 7.58, df = 1, p < 0.01). Male height was the second most important factor, and smoking cessation the only other variable which significantly influenced the risk of recurrence.
Analysis of several potential risk factors revealed that recurrence was not related to the BMI of the patient, the initial treatment of the pneumothorax, nor to its size. Recurrence was more common in taller men and in women. Smoking cessation appeared to reduce the risk of recurrence. These findings are discussed in the context of the possible aetiology of spontaneous pneumothorax, recurrences, and the management thereof.
原发性自发性气胸(PSP)是一个常见的临床问题,其发病率据认为正在上升。复发风险很高,各项研究报告的复发率为20% - 60%。可能导致或不导致复发的因素尚未确定。
在为期四年的研究期间,对291例诊断为气胸的病例进行了回顾;153例PSP患者被纳入研究。特别参照以下变量分析了他们的复发风险:患者的年龄、性别、身高和体重指数(BMI)、气胸的初始大小、患者的吸烟状况以及采用的主要治疗方式。通过卡方检验进行单因素分析,并通过逻辑回归模型计算多因素分析。
对153例患者在四年期间发生的275次PSP发作进行的回顾性研究证实复发率很高(54.2%)。PSP在男性中的发生率是女性的两倍,不过女性复发的可能性明显更高(卡方 = 7.58,自由度 = 1,p < 0.01)。男性身高是第二重要的因素,戒烟是唯一显著影响复发风险的其他变量。
对几个潜在风险因素的分析表明,复发与患者的BMI、气胸的初始治疗及其大小均无关。复发在较高的男性和女性中更为常见。戒烟似乎可降低复发风险。在自发性气胸的可能病因、复发及其处理的背景下对这些发现进行了讨论。