喹诺酮类药物对铜绿假单胞菌多药外排系统的差异选择
Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa.
作者信息
Köhler T, Michea-Hamzehpour M, Plesiat P, Kahr A L, Pechere J C
机构信息
Department of Genetics and Microbiology, Centre Médical Universitaire, Geneva, Switzerland.
出版信息
Antimicrob Agents Chemother. 1997 Nov;41(11):2540-3. doi: 10.1128/AAC.41.11.2540.
Abstract
Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.
摘要
对铜绿假单胞菌在体外暴露于12种喹诺酮类药物后所选择的耐药机制进行了分析。外排型突变体占主导。喹诺酮类药物在选择特定外排系统的能力上存在差异。较新的氟喹诺酮类药物倾向于选择MexCD - OprJ系统，而较老的喹诺酮类药物则仅选择MexEF - OprN或MexAB - OprM系统。可质子化的C - 7取代基与C - 6氟原子相结合是参与外排泵底物特异性的喹诺酮类药物的结构决定因素。
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