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喹诺酮-青霉烯类化合物在基因明确的大肠杆菌菌株中的构效关系研究。

Structure-activity studies of quinolone-penems in genetically defined strains of Escherichia coli.

作者信息

Ehrhardt A F, Sanders C C

机构信息

Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.

出版信息

Antimicrob Agents Chemother. 1997 Nov;41(11):2570-2. doi: 10.1128/AAC.41.11.2570.

DOI:10.1128/AAC.41.11.2570
PMID:9371371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC164166/
Abstract

Quinolonyl-beta-lactam antimicrobial agents (QLAs) contain quinolones chemically linked to beta-lactams, although the impact of linkage is poorly understood. Genetically defined Escherichia coli strains were used to determine structure-activity characteristics of three quinolone-penem QLAs. Results suggest that the leaving group resulting from beta-lactam hydrolysis may not be free quinolone.

摘要

喹诺酮基-β-内酰胺抗菌剂（QLAs）含有化学连接到β-内酰胺的喹诺酮，尽管连接的影响尚不清楚。使用基因定义的大肠杆菌菌株来确定三种喹诺酮-青霉烯QLAs的构效特征。结果表明，β-内酰胺水解产生的离去基团可能不是游离喹诺酮。

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Structure-activity studies of quinolone-penems in genetically defined strains of Escherichia coli.喹诺酮-青霉烯类化合物在基因明确的大肠杆菌菌株中的构效关系研究。
Antimicrob Agents Chemother. 1997 Nov;41(11):2570-2. doi: 10.1128/AAC.41.11.2570.
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