Abi-Dargham A, Innis R B, Wisniewski G, Baldwin R M, Neumeyer J L, Seibyl J P
Department of Psychiatry, Yale University School of Medicine and VA Medical Center, West Haven, Conn., USA.
Eur J Nucl Med. 1997 Nov;24(11):1422-5. doi: 10.1007/s002590050170.
Two new N-omega-fluoroalkyl analogs of [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([123I]beta-CIT), the fluoroethyl and fluoropropyl compounds ([123I]FE-CIT and [123I]FP-CIT, respectively), have been shown to have faster kinetics and better selectivity for the dopamine transporter than [123I]beta-CIT. We examined the organ biodistribution and radiation safety of these two compounds in six healthy volunteers who received an injection with each of the two compounds 2 weeks apart. Data were obtained on the Strichman 860 whole-body scanner. Transmission scans were obtained in all subjects prior to the injection of the radiotracer with a line source and used to derive organ-specific attenuation correction factors. Whole-body planar images were acquired every hour for the first 6 h, and at 24 h. Attenuation-corrected regional conjugate counts were converted into units of activity using a calibration factor obtained for each subject by dividing whole-body conjugate decay-corrected counts from the first acquisition by the injected activity. Radiation dose estimates were on average higher for [123I]CIT-FE than for [123I]CIT-FP, with the lower large intestine receiving the highest exposure: 0.15+/-13% mGy/MBq (mean +/-COV) and 0.12+/-14% mGy/MBq for [123I]FE-CIT and [123I]FP-CIT, respectively, followed by the upper large intestine and the spleen.
[123I]2β-甲氧羰基-3β-(4-碘苯基)托烷([123I]β-CIT)的两种新型N-ω-氟烷基类似物，即氟乙基和氟丙基化合物(分别为[123I]FE-CIT和[123I]FP-CIT)，已被证明比[123I]β-CIT具有更快的动力学和对多巴胺转运体更好的选择性。我们在6名健康志愿者中研究了这两种化合物的器官生物分布和辐射安全性，这些志愿者每隔2周分别接受这两种化合物中的一种注射。数据是在Strichman 860全身扫描仪上获得的。在注射放射性示踪剂之前，用线源对所有受试者进行透射扫描，并用于推导器官特异性衰减校正因子。在最初的6小时内每小时采集全身平面图像，并在24小时采集。使用通过将第一次采集的全身共轭衰变校正计数除以注射活度为每个受试者获得的校准因子，将衰减校正后的区域共轭计数转换为活度单位。[123I]CIT-FE的辐射剂量估计平均高于[123I]CIT-FP，其中降结肠接受的辐射最高：[123I]FE-CIT和[123I]FP-CIT分别为0.15±13%mGy/MBq(平均值±变异系数)和0.12±14%mGy/MBq，其次是升结肠和脾脏。
